GM-CSF Protéine

N° du produit ABIN987972

Protéine Recombinant GM-CSF exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour GM-CSF Protéine (ABIN987972)

Antigène: GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 95 % by SDS-PAGE and Commassie blue staining

Détail du produit

Séquence: MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQana lysis The sequence of the first five N-terminal amino acids has been found to be (Met)-Ala-Pro-Ala-Arg-Ser

Attributs du produit: Determined by the dose-dependant stimulation of human TF-1 cells. The ED50 for this effect is 0.24-0.36 ng/ml.

niveau d'endotoxine: Level Less than 0.1 ng/µg (1 EU/myg) determined by LAL tes

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Stock: -20 °C

Détail du antigène

Antigène: GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))

Autre désignation: Granulocyte Macrophage Colony Stimulating Factor

Sujet: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites. Synonym: GM-CSF, E.coli2. Formulation: Lyophilized from a 0.2 mym filtered solution in 2 mM PB, pH 7.4.

Pathways: Signalistation JAK/STAT, Cellular Response to Molecule of Bacterial Origin